Prof. Emmanuel Bachy (MD, PhD)
After a first career in mathematics at the French Ecole Polytechnique in 1998, Prof. Emmanuel Bachy orientated his career towards medicine. He obtained his M.D. degree in clinical hematology in 2010 and his Ph.D. in fundamental immunology in 2012 from the Lyon University in France.
Most of his PhD was devoted to developing a mouse model of lymphomagenesis in a context of chronic stimulation by bacterial antigens. He and his team identified a previously unsuspected cell of origin for a murine and human T-cell lymphoma subtype. They demonstrated that this peculiar subtype possesses a T-cell receptor (TCR) that does not recognize conventional MHC class I or II and peptide complexes but alternatively that interacts with a MHC class I-like molecule called CD1d presenting glycolipids instead of peptides. Importantly, in a mouse model, blocking the CD1d-sulfatide interaction with the TCR by monoclonal antibodies significantly prolonged survival.
In 2015, he has joined the team of Dr Staudt at the National Institute of Health in Bethesda (MD, USA). He set up and performed whole genome CRISPR-Cas9 screens in peripheral T-cell lymphoma cell lines uncovering new therapeutic targets and essential signaling genes in the disease. In parallel to basic science research, he has participated to or led many clinical and translational research programs concerning various aspects of the hematology field.
He is Associate Professor of Hematology since 2019 and is now co-leading his own research team amongst the Lyon Cancer Center Research with a particular focus on high throughput sequencing approaches for therapeutic innovation in mature T-cell lymphomas. He is also co-chair of the clinical hematology department in Lyon, France. He has published more than 70 articles in journals such as Nature, Cancer Cell, Blood, J Clin Oncol, Ann Oncol, or J Exp Med.
Research Areas
- Cancer research in peripheral T-cell lymphoma
- CAR T cells therapy for B-cell lymphoma
- CRISPR-Cas9 technology
- Prognosis and diagnosis signatures using epigenetics
Contact Information
Prof. Emmanuel Bachy
Hôpital Lyon Sud
Bâtiment 1F, Service d’hématologie, Etage 3
165 chemin du Grand Revoyet
69495 Pierre Bénite FRANCE
tel : +33(0)478862205
email : emmanuel.bachy@chu-lyon.fr
