Releases

Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling

Authors: Oberbeck S, Schrader A, Warner K, Jungherz D, Crispatzu G, von Jan J, Chmielewski M, Ianevski A, Diebner HH, Mayer P, Kondo Ados A, Wahnschaffe L, Braun T, Müller TA, Wagle P, Bouska A, Neumann T, Pützer S, Varghese L, Pflug N, Thelen M, Makalowski J, Riet N, Göx HJM, Rappl G, Altmüller J, Kotrova M, Persigehl T, Hopfinger G, Hansmann ML, Schlößer H, Stilgenbauer S, Dürig J, Mougiakakos D, von Bergwelt-Baildon M, Roeder I, Hartmann S, Hallek M, Moriggl RH, Brüggemann M, Aittokallio T, Iqbal J, Newrzela S, Abken H, Herling M.
Journal: Blood, 2020 Sep 21:blood.2019003348 (https://doi.org/10.1182/blood.2019003348)
What to Look Out for when Transplanting T-Cell Prolymphocytic Leukemia

Authors: Wahnschaffe L, Herling M
Journal: Acta Haematol 2020. (10.1159/000507415)
Reconstruction of rearranged T‐cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T‐cell prolymphocytic leukemia

Authors: Paurnima Patil, Agata Cieslak, Stephan H. Bernhart, Umut H. Toprak, Rabea Wagener, Cristina López, Laura Wiehle, Susanne Bens, Janine Altmüller, Marek Franitza, Ingrid Scholz, Sandrine Jayne, Matthew J. Ahearne, Annika Scheffold, Billy M. C. Jebaraj, Christof Schneider, Dolors Costa, Till Braun, Alexandra Schrader, Elias Campo, Martin J. S. Dyer, Peter Nürnberg, Jan Dürig, Patricia Johansson, Sebastian Böttcher, Matthias Schlesner, Marco Herling, Stephan Stilgenbauer, Elizabeth Macintyre, Reiner Siebert
Journal: Genes Chromosomes Cancer, 29 October 2020, 59:261–267 (http:// https://doi.org/10.1002/gcc.22821)
Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine

Authors: S. Pützer, L. Varghese, J. von Jan, T. Braun, A. K. Giri, P. Mayer, N. Riet, S. Timonen, S. Oberbeck, H. Kuusanmäki, S. Mustjoki, M.-H. Stern, T. Aittokallio, S. Newrzela, A. Schrader & M. Herling
Journal: Leukemia. 25 February 2020 (https://doi.org/10.1038/s41375-020-0772-6)
Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

Authors: Abdeldayem A., Raouf Y.S., Constantinescu S., Moriggl R., Gunning P.T.
Journal: Chem. Soc. Rev. 2020
The Stromal Microenvironment Provides An Escape Route From FLT3 Inhibitors Through The GAS6-AXL-STAT5 Axis

Authors: Anna Orlova, Heidi A. Neubauer, Richard Moriggl
Journal: Haematologica October 2019 104: 1907-1909 (https://doi.org/10.3324/haematol.2019.225862)
Advances in Covalent Inhibitors for Kinases

Authors: Abdeldayem A., Raouf Y.S., Constantinescu S., Moriggl R., Gunning P.T.
Journal: Chem. Soc. Rev. 2020
JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL.

Authors: Linus Wahnschaffe, Till Braun, Sanna Timonen, Anil K. Giri, Alexandra Schrader, Prerana Wagle, Henrikki Almusa, Patricia Johansson, Dorine Bellanger, Cristina López, Claudia Haferlach, Marc-Henri Stern, Jan Dürig, Reiner Siebert, Satu Mustjoki, Tero Aittokallio and Marco Herling
Journal: Cancers 11(12), 1833. Published: 21 November 2019 (https://doi.org/10.3390/cancers11121833)
Advances and Perspectives in the Treatment of T-PLL

Authors: Till Braun, Jana von Jan, Linus Wahnschaffe, Marco Herling
Journal: Current Hematologic Malignancy Reports, 7 February 2020 (10.1007/s11899-020-00566-5)

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